Josefina Casas Selected Research

Inflammation (Inflammations)

9/2023	Obesity promotes fumonisin B1 hepatotoxicity.
6/2023	Modulation of Dietary Choline Uptake in a Mouse Model of Acid Sphingomyelinase Deficiency.
1/2018	Mechanistically different effects of fat and sugar on insulin resistance, hypertension, and gut microbiota in rats.
1/2018	Functional Effects of the Buckwheat Iminosugar d-Fagomine on Rats with Diet-Induced Prediabetes.
8/2017	Myriocin treatment of CF lung infection and inflammation: complex analyses for enigmatic lipids.
6/2016	Inhibition of ceramide de novo synthesis by myriocin produces the double effect of reducing pathological inflammation and exerting antifungal activity against A. fumigatus airways infection.
5/2016	Inhibitors of sphingosine-1-phosphate metabolism (sphingosine kinases and sphingosine-1-phosphate lyase).
1/2016	De novo ceramide synthesis is involved in acute inflammation during labor.
12/2015	Myristic acid potentiates palmitic acid-induced lipotoxicity and steatohepatitis associated with lipodystrophy by sustaning de novo ceramide synthesis.
1/2014	Anti-inflammatory action of lipid nanocarrier-delivered myriocin: therapeutic potential in cystic fibrosis.

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Josefina Casas Research Topics

Disease

27	Neoplasms (Cancer) 12/2023 - 04/2007
11	Inflammation (Inflammations) 09/2023 - 05/2013
8	Infections 08/2023 - 07/2010
7	Gaucher Disease (Gaucher's Disease) 10/2022 - 07/2007
5	Obesity 09/2023 - 08/2014
4	West Nile Fever 12/2023 - 10/2014
4	Body Weight (Weight, Body) 09/2023 - 01/2018
4	Flavivirus Infections 01/2023 - 01/2016
4	Alzheimer Disease (Alzheimer's Disease) 10/2021 - 02/2018
4	Melanoma (Melanoma, Malignant) 11/2020 - 01/2011
4	Glioma (Gliomas) 11/2016 - 01/2011
3	Type C Niemann-Pick Disease (Niemann Pick Disease, Type C) 04/2024 - 11/2020
3	Niemann-Pick Diseases (Niemann Pick Disease) 06/2023 - 11/2020
3	Fatty Liver 06/2023 - 12/2015
3	Breast Neoplasms (Breast Cancer) 01/2023 - 06/2012
3	Cystic Fibrosis (Mucoviscidosis) 08/2017 - 08/2013
3	Choriocarcinoma 01/2015 - 06/2014
2	Amyloid Plaque 10/2021 - 01/2019
2	Non-alcoholic Fatty Liver Disease 01/2020 - 12/2015
2	Glucose Intolerance 01/2020 - 01/2018
2	Hypertension (High Blood Pressure) 01/2020 - 01/2018
2	Hypoxia (Hypoxemia) 06/2019 - 01/2018
2	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2019 - 04/2014
2	Amyloidosis 01/2019 - 02/2018
2	Pancreatitis 01/2018 - 05/2013
2	Insulin Resistance 01/2018 - 01/2018
2	Chronic Obstructive Pulmonary Disease (COPD) 08/2017 - 06/2016
2	Pneumonia (Pneumonitis) 08/2017 - 06/2016
2	Retinitis Pigmentosa (Pigmentary Retinopathy) 07/2017 - 05/2013
2	Stomach Neoplasms (Stomach Cancer) 01/2017 - 09/2009
2	Carcinogenesis 05/2016 - 05/2013
2	Farber Lipogranulomatosis 08/2014 - 06/2013
2	Prostatic Neoplasms (Prostate Cancer) 05/2013 - 07/2011
2	Carcinoma (Carcinomatosis) 12/2012 - 10/2011
1	Cerebellar Diseases (Cerebellar Syndrome) 04/2024
1	Disease Progression 12/2023
1	Coronavirus Infections 08/2023
1	Addison Disease (Addison's Disease) 01/2023
1	Adrenocortical Carcinoma 01/2023
1	Nephrotic Syndrome (Syndrome, Nephrotic) 01/2023

Drug/Important Bio-Agent (IBA)

22	SphingolipidsIBA 12/2023 - 11/2011
18	CeramidesIBA 12/2023 - 07/2011
18	LipidsIBA 12/2023 - 01/2011
17	EnzymesIBA 01/2023 - 07/2007
9	Acid CeramidaseIBA 12/2023 - 04/2007
5	AcidsIBA 06/2023 - 01/2016
5	Sphingomyelin Phosphodiesterase (Sphingomyelinase)IBA 06/2023 - 08/2014
5	Glucosylceramidase (Glucocerebrosidase)IBA 10/2022 - 07/2007
5	dihydroceramideIBA 01/2021 - 09/2009
4	CholesterolIBA 04/2024 - 12/2015
4	Biomarkers (Surrogate Marker)IBA 12/2023 - 01/2018
4	SphingomyelinsIBA 01/2023 - 08/2014
4	Fatty Acids (Saturated Fatty Acids)IBA 10/2021 - 05/2013
4	CeramidasesIBA 04/2021 - 08/2011
4	dihydroceramide desaturaseIBA 02/2018 - 07/2010
3	Antiviral Agents (Antivirals)IBA 08/2023 - 01/2019
3	Amyloid (Amyloid Fibrils)IBA 10/2021 - 02/2018
3	Glucose (Dextrose)FDA LinkGeneric 01/2020 - 01/2018
3	DiglyceridesIBA 01/2020 - 01/2018
3	Dinoprostone (PGE2)FDA Link 01/2018 - 08/2013
3	thermozymocidin (myriocin)IBA 08/2017 - 01/2014
3	GlycosidesIBA 09/2015 - 01/2011
3	Glucosylceramides (Glucocerebrosides)IBA 01/2014 - 03/2009
2	Blood Glucose (Blood Sugar)IBA 09/2023 - 01/2018
2	Glycerophospholipids (Phosphoglycerides)IBA 06/2023 - 10/2014
2	pachastrissamineIBA 06/2022 - 01/2017
2	Phosphotransferases (Kinase)IBA 01/2022 - 01/2021
2	Peptides (Polypeptides)IBA 10/2021 - 01/2019
2	Dronabinol (THC)FDA LinkGeneric 01/2021 - 11/2016
2	Acetyl-CoA CarboxylaseIBA 01/2021 - 01/2019
2	AMP-Activated Protein KinasesIBA 01/2021 - 01/2018
2	GalactosylceramidaseIBA 11/2020 - 04/2014
2	EndocannabinoidsIBA 11/2020 - 01/2019
2	LeptinIBA 01/2020 - 01/2018
2	fagomineIBA 01/2020 - 01/2018
2	FructoseIBA 01/2020 - 01/2018
2	Uric Acid (Urate)IBA 01/2020 - 01/2018
2	Carnitine O-Palmitoyltransferase (Carnitine Palmitoyltransferase II)IBA 01/2020 - 01/2014
2	Hormones (Hormone)IBA 01/2019 - 07/2011
2	Oleic Acid (Oleate)IBA 01/2018 - 05/2013
2	AntioxidantsIBA 01/2018 - 01/2015
2	Interleukin-6 (Interleukin 6)IBA 01/2018 - 01/2016
2	SphingosineIBA 05/2016 - 06/2012
2	Nonesterified Fatty Acids (NEFA)IBA 12/2015 - 05/2013
2	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 12/2013 - 05/2013
2	(2R,3Z)- N- (1- hydroxyoctadec- 3- en- 2- yl)pivalamideIBA 06/2012 - 07/2011
2	Antineoplastic Agents (Antineoplastics)IBA 05/2012 - 07/2011
2	Antimitotic AgentsIBA 10/2011 - 01/2011
1	S-Adenosylmethionine (Ademetionine)IBA 04/2024
1	MycotoxinsIBA 09/2023
1	Transaminases (Aminotransferases)IBA 09/2023
1	Drinking WaterIBA 09/2023
1	fumonisin B1IBA 09/2023
1	CyclodextrinsIBA 08/2023
1	Choline (Choline Chloride)IBA 06/2023
1	sphingosine 1-phosphate lyase (aldolase)IBA 01/2023
1	AnthracyclinesIBA 01/2023
1	CalciumIBA 01/2023

Therapy/Procedure

8	Therapeutics 12/2023 - 05/2012
6	Drug Therapy (Chemotherapy) 01/2018 - 04/2007